Tuesday: Nucleic Acid-Binding Proteins
Goals of the day - Protein interactions in major/minor groove. Direct/indirect readout. Allostery and regulation.

• My preliminary lecture notes protein-nucleic acid interactions, updated on 10/6
• Read V&V Ch. 31.3 or G&G Ch. 29.2
• My powerpoint slides
• Additional Reading
• Wolfe et al. (2000) DNA Recognition by Zn Fingers
• Mauro et al. (2003) Indirect Readout by the 434 Repressor

Thursday: Membrane Proteins and GPCRs
Goals of the day - Some principles of membrane protein structure. Role of GPCRs. Allostery and Orthostery. Structure, and impact of agonists and antagonists.

• A story that I have yet to put in notes. Apology.
• My powerpoint slides
• Additional Reading
• Smith (2010) Structure and Activation of the Visual Pigment Rhodopsin
• Katrich et al. (2013) Structure-Function of the G Protein-Coupled Receptor Superfamily