Tuesday: Catalytic Antibodies, Drawing mechanisms
Goals of the day - Transition state binding, competitive inhibition. How to push arrows in Biochem.

• My lecture notes on enzyme kinetics
• My lecture notes on catalytic antibodies
• Mhandout on rate pH profiles
• My powerpoint slides
• Articles on the cocaine hydrolyzing antibody characterization and Crystallographic study of reaction cycle

Thursday: General Acid/Base Catalysis
Goals of the day - Mechanism of competitive inhibition. Activity-pH profiles. pKa tuning by environment.

• My lecture notes on general acid/base catalysis
• My lecture notes on triose phosphate isomerase
• My notes on catalysis of RNA hydrolysis
• My powerpoint slides
• Additional Reading
• Good review by Ron Raines on RNase A.
• Article by Ron Raines on GA/GB catalysis by RNase A.
• Two reviews on Triose Phosphate Isomerase from Jeremy Knowles: Not Different, Just Better and To Build an Enzyme