Tuesday: More on Nucleic Acid Structure
Goals of the day - Secondary and tertiary structure in DNA. Watson-Crick base pairing, the Double Helix and its stability

• My lecture notes nucleic acid structure
• Read V&V Ch. 7.6, 29 or G&G Ch. 10-11
• My powerpoint slides
• Additional Reading
• Ho & Carter DNA Structure: Alphabet Soup for the Cellular Soul

Thursday: Ligand binding and Aptamers
Goals of the day - Functional RNA. Receptor-ligand interactions and binding algebra. Intermolecular interactions and binding affinity/specificity.

• My lecture notes ligand binding
• My notes on aptamers are coming
• My powerpoint slides
• Additional Reading
• Silverman (2007) Artificial Functional Nucleic Acids
• Garst et al. (2011) Riboswitches: Structure and Mechanism
• Breaker (2012) Riboswitches and the RNA World