Tuesday: Amino Acids and Protein Primary Structure
Goals of the day - Describing amino acid structures and properties. Central Dogma and protein biosynthesis. Solid phase synthesis of peptides. Determining properties of the protein molecule defined by its sequence.

• My lecture notes on protein primary structure.
• My lecture notes on protein mass spec
• Read V&V Ch. 4, 7.1, 7.5 or G&G Ch. 4-5
• My powerpoint slides
• Additional Reading
• Seidler et al. (2010) De Novo sequencing of peptides by MS/MS. (Wiley link in upper right-hand corner will take you to pdf).

Thursday: Protein Secondary Structure
Goals of the day - Understand classes of secondary structure and rationale for its presence in peptide chains. Measurement of secondary structure by circular dichroism spectroscopy. Factors contributing ot the stabilization of isolated secondary structure elements.

• My lecture notes on protein secondary structure.
• My lecture notes on circular dichroism spectroscopy
• Read V&V Ch. 8 or G&G Ch. 6
• My powerpoint slides
• Additional Reading
• Pauling's orginal paper on helices
• Modern retrospective on Pauling's discovery.
• Good tutorial on circular dichroism spectroscopy.