Tuesday: Aptamers and Riboswitches
Goals of the day - Functional RNA. Receptor-ligand interactions. Intermolecular interactions and binding affinity/specificity.

• My lecture notes ligand binding
• My lecture notes on RNA aptamers
• My powerpoint slides
• Additional Reading
• Silverman (2007) Artificial Functional Nucleic Acids
• Jenison et al. (1994) High-Resolution Molecular Discrimination by RNA
• Breaker (2012) Riboswitches and the RNA World

Thursday: Nucleic Acid-Binding Proteins
Goals of the day - Protein interactions in major/minor groove. Direct/indirect readout. Allostery and regulation.

• My lecture notes on protein-nucleic acid interactions.
• My powerpoint slides
• Read V&V Ch. 31.3 or MoL
• Additional Reading
• Wolfe et al. (2000) DNA Recognition by Zn Fingers
• Mauro et al. (2003) Indirect Readout by the 434 Repressor