Tuesday: Intro to Thermodynamics
Goals of the day - relate magnitude of an equilibrium constant to ∆G; distinguish between enthalpic and entropic contributions to ∆G; relate IMF's to distance and ∆H value, understanding of how the hydrophobic effect is an entropic contribution to order.

• My lecture notes
• Overheads from lecture
• Read V&V Ch. 2-3 or MofL Ch. 1.A, and Section 12.22
• Additional Reading
• Creighton, Proteins, Ch. 4 (source of much of my notes; on reserve)
• Dunitz (1994) The Entropic Cost of Bound Water Molecules. Short rumination on entropy
• Silverstein (1998) The Real Reason Why Oil and Water Don't Mix. The pedagogy of the hydrophobic effect

Thursday: Lipids and Fluorescence
Goals of the day - Lipid aggregation to form structures will be used to highlight IMFs and the hydrophobic effect. We'll be reading a paper that uses fluorescence techniques to monitor liposome size, so better introduce the technique.

• My lecture notes on lipids and on fluorescence.
• Overheads from lecture
• Read V&V Ch. 4, 7.1, 7.5 and 12.1-3 or MoL Ch. 1.10-12
• Additional Reading
• Deamer (1985) Discovery of Boundary Forming Molecules in a meteorite, and nice recent review on protocells.
• On-line textbook descriptions of fluorescence and FRET
• A moderately recent review of fluorophores used in biological settings.