Tuesday: Amino acyl tRNA synthetases
Goals of the day - Specificity in catalysis - with respect to amino acid and tRNA substrates. The Hopfield mechanism.

• My notes on amino acyl tRNA synthtases.
• A handout on the Hopfield mechanism.
• My powerpoint slides
• Additional Reading
• JJ Hopfield (1974) Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity. PNAS, 71, 4135-4139.
• Moras (2010) Proofreading in translation: Dynamics of the double-sieve. PNAS 107, 21949. Quick recent review of aaRS proofreading.
• At last! The structure of AlaRS bound to a cognate and non-cognate tRNA. Also a nice quick review.

Thursday: On to the Ribosome
Goals of the day - On to the ribosome and translation. tRNA structure/function. Structure of the ribosome. RNA catalysis

• My notes on the ribosome and translation
• My powerpoint slides
• Additional Reading
• Review of ribosome structures, ca. 2009