Tuesday: Nucleophilic Catalysis/Glycosidases
Goals of the day - Dissection of the catalytic triad and oxyanion hole in serine protases. Polysaccharides in biochemisty. Glycosidases.

• My powerpoint slides
• Additional Reading
• Read V&V Ch. 11, 15.2 or G&G Ch. 7,
• Review article on Serine Proteases
• Vocaldo et al. (2001) Catalysis by HEW lysozyme proceeds via a covalent intermediate.

Thursday: Lewis Acid Catalysis
Goals of the day - Metal ions in catalysis. Activation of electrophiles and nucleophiles. A decarboxylase, nitrile hydratase and carbonic anhydrase.

• My notes on Lewis acid catalysis.
• My powerpoint slides
• Additional Reading
• Really good review on Carbonic Anhydrase (pp 33-43)
• Nitrile hydratase Time-resolved crystallography!