Tuesday: Stability of Secondary Structure
Goals of the day - Stabilization of the alpha helix. Fibrous proteins.
- My lecture notes on protein secondary structure
- Overheads on tertiary structure
- Read V&V Ch. 4, 7.1, 7.5 or MofL
- Additional Reading
- Shoemaker et al. (1987) Test of the helix dipole model for stabilization of alpha helices. Nature, 326, 563-567.
Thursday: Tertiary and Quaternary Structure.
Goals of the day - Measuring stability of tertiary structure, some case studies. Quaternary structure.
- Some lecture notes on protein stability.
- Overheads on tertiary structure
- Read V&V Ch. 8 or MofL
- Additional Reading
- V. Bloomfield's on-line notes on thermodynamics.
- Nice review by N. Pace on stability
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