Tuesday: Protein primary structure and Mass Spec
Goals of the day - Covalent structure in proteins, sequence determination by Mass Spec.

• My lecture notes on amino acids and protein primary structure.
• My lecture notes on protein mass spec
• Additional Reading
• Read V&V Ch. 4, 7.1, 7.5 or MofL Ch. 1.10
• My powerpoint slides
• Additional Reading
• Seidler et al. (2010) De Novo sequencing of peptides by MS/MS. (Wiley link in upper right-hand corner will take you to pdf).

Thursday: Protein Secondary Structure
Goals of the day - Understand classes of secondary structure and rationale for its presence in peptide chains. Measurement of secondary structure by circular dichroism spectroscopy.

• My lecture notes on protein secondary structure
• My lecture notes on circular dichroism spectroscopy
• My powerpoint slides
• Good tutorial on circular dichroism spectroscopy.
• My Introduction to PyMOL (not related to this class meeting)
• Additional Reading
• Pauling's orginal paper on helices
• Modern retrospective on Pauling's discovery.