Tuesday: Nucleophilic Catalysis
Goals of the day - Bisubstrate reactions, the catalytic triad and oxyanion hole in serine protases.

• My powerpoint slides
• Additional Reading
• Read V&V Ch. 11, 15.2 or MofL 16.C
• Review article on Serine Proteases

Thursday: Lewis Acid Catalysis/Enzyme Cofactors
Goals of the day - Metal ions and other cofactors in catalysis.

• My notes on Lewis acid catalysis.
• My notes on decarboxylases.
• My powerpoint slides
• Additional Reading
• Really good review on Carbonic Anhydrase (pp 33-43)
• Nitrile hydratase Time-resolved crystallography!
• Carbonic anhydrase reacting with CO2 in a crystal